Introducing
An scCO2-sterilized amniotic membrane developed around a simple principle: the terminal step should help protect the tissue’s biological and structural value.
For professional and institutional education.
In a 2025 laboratory study, scCO2-sterilized amniotic membrane showed the following average fold increases versus commercially available gamma-irradiated samples tested.
Angiogenic signaling
Fibroblast signaling
Cell differentiation
Matrix regulation
Growth-factor modulation
Cell signaling
Absent in the irradiated samples tested: bFGF, BMP-4, growth hormone (GH), and stem cell factor (SCF) were reported as completely absent from both gamma and e-beam samples in the study.
Fold values reflect mean concentrations reported in Table 1; scCO2 n=3 donors and gamma n=3 donors. Results are laboratory findings and may vary by donor, processing, storage, and assay.
View source study →Histologic evaluation in the same published study found that scCO2-processed tissue more closely resembled fresh amniotic membrane, while gamma-irradiated tissue showed areas of stromal degradation and fiber compaction.
Mostly preserved collagen stroma; basement membrane remained visible in the reported sections.
Areas of collagen degradation and fiber compaction; basement membrane was less distinguishable.
Conceptual illustration – not a microscopy image.
A versatile selection of graft dimensions for product selection and treatment planning.
Ask about availability →The product story is grounded in published laboratory and histologic findings. Review the source literature for complete methods, limitations, and context.
O’Connell J, et al. Development of a sterilization process for amniotic membrane allograft tissue using supercritical carbon dioxide and NovaKill. Cell Tissue Bank. 2025;26:4.
doi:10.1007/s10561-024-10152-1Paolin A, et al. Cytokine expression and ultrastructural alterations in fresh-frozen, freeze-dried and gamma-irradiated human amniotic membranes. Cell Tissue Bank. 2016;17:399-406.
doi:10.1007/s10561-016-9553-xSuroto H, et al. The influence of preservation method and gamma irradiation sterilization on TGF-beta and bFGF levels. Int J Biomater. 2021;2021:6685225.
doi:10.1155/2021/6685225This material summarizes published laboratory and histologic findings about tissue composition and structure. These data do not, by themselves, establish superior clinical outcomes, improved healing rates, or superiority for any specific indication. Product-specific decisions should be based on the complete source literature, product labeling, regulatory status, clinical judgment, and applicable FDA and FTC requirements. For professional and institutional education.
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